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- BookKendall A. Smith.Contents:
Chapter 1. Introduction - The Evolution of Our Understanding of the Immune System
Chapter 2. Molecular Immunology
Chapter 3. The Problem - Understanding How Molecules Direct the Behavior of Cells Comprising the Immune System
Chapter 4. The Quantal Theory of Immunity
Chapter 5. The Variability of Cell Cycle Progression and the Competence and Progression Phases of the Cell Cycle
Chapter 6. The Quantal Nature of IL-2-Promoted T Cell Cycle Progression
Chapter 7. The Molecular Basis for Quantal IL-2/IL-2R Signaling of Cell Cycle Progression - The IL-2/Receptor Interaction
Chapter 8. The Molecular Basis for Quantal IL-2/IL-2R Signaling of Cell Cycle Progression - IL-2 and IL-2 Receptor Metabolism
Chapter 9. The Molecular Basis for Quantal IL-2/IL-2R Signaling of Cell Cycle Progression - IL-2 Receptor Signaling via the Jak/Stat Pathway
Chapter 10. The Molecular Basis for Quantal IL-2/IL-2R Signaling of Cell Cycle Progression - IL-2 Receptor Signaling via Phosphorylation of IL-2R β Chain Y338
Chapter 11. The T Cell Antigen Receptor Complex and the Quantal Regulation of the IL-2 and IL-2R Genes
Chapter 12. Digital Signaling via the T Cell Antigen Receptor Complex
Chapter 13. Negative Feedback Regulation of T Cell Antigen Receptor Complex Signaling - Attenuation of IL-2 Gene Expression
Chapter 14. The Paradox of the IL-2 (-/-) Mouse
Chapter 15. The Scurfy Mouse
Chapter 16. Lymphopenia, Autoimmunity and the Regulatory T Cell (Treg)
Chapter 17. Treg-mediated "Active Suppression" of T Cell Proliferation
Chapter 18. FOXP3, A Better ID-Tag for Tregs?
Chapter 19. Mice Versus Men
Chapter 20. Active Versus Passive Suppression and IL-2 Metabolism
Chapter 21. FOXP3 Restricts But Does Not Suppress IL-2 Production
Chapter 22. Both the TCR and IL-2 Regulate Foxp3 Expression
Chapter 23. The Effects of FOXP3 Expression
Chapter 24. Role of IL-2 in the Generation of Immune Responses In Vivo
Chapter 25. The Role of the IL-2r Chains in IL-2 Signaling, Consumption and Suppression of T Cell Proliferation
Chapter 26. T Cell Tissue-specific Autoimmunity
Chapter 27. Type 1 Diabetes Mellitus (TIDM), a Prototypic Genetic Autoimmune Disease with a Tie to IL-2
Chapter 28. The Pathogenesis of Leukemia - Loss of Normal Quantal Growth Control.